Ịghọta Tricalcium Phosphate: Uru, Ojiji, na Ntụnyere Mgbakwunye Calcium

Tricalcium phosphate, ụdị a kapịrị ọnụ nke calcium phosphate, na-arụ ọrụ dị mkpa na ngwa ụlọ ọrụ mmepụta ihe na ahụike mmadụ, karịsịa dị ka ihe mgbakwunye nri maka oriri calcium. Edemede a na-enyocha ihe tricalcium phosphate bụ, uru ya maka ahụike ọkpụkpụ, otu o si akwado ụdị calcium ndị ọzọ dị ka calcium citrate, ihe ize ndụ ahụike, na isi mmalite ya. Ịghọta ogige a dị oké mkpa ma ị na-ewere ya dị ka mgbakwunye iji lụso osteoporosis ọgụ ma ọ bụ izute ya na ngwaahịa nri, na-eme ka ị na-eme mkpebi ziri ezi gbasara mkpa calcium nri gị. Gụkwuo ka ịchọpụta eziokwu ndị dị mkpa gbasara tricalcium phosphate.

Kedu ihe bụ Tricalcium Phosphate?

Tricalcium phosphate (TCP), mgbe ụfọdụ a na-ezo aka naanị dị ka calcium phosphate, bụ ihe ịnweta mineral nwere usoro kemịkal Ca₃(PO₄)₂. Ọ bụ n'ezie a calcium nnu nke phosphoric acid. Ị nwere ike izute ya edepụtara dị ka calcium phosphate tribasic ma ọ bụ ọkpụkpụ phosphate nke lime (BPL), karịsịa mgbe e sitere na isi mmalite dị ka ọkpụkpụ ọkpụkpụ. Ngwakọta a bụ akụkụ bụ isi nke ọkpụkpụ vertebrate na ezé, na-eme ka akụkụ dị ịrịba ama nke nhazi ịnweta ha.

N'ụdị ya dị ọcha. tricalcium phosphate na-apụta dị ka ọcha, enweghị isi, ntụ ntụ kristal. Ọ bụ ihe na-esighi ike na mmiri mana ọ nwere ike igbari na acid dilute. Njirimara a dị mkpa maka ọrụ ndu ya na ngwa mmepụta ihe. Ọnụnọ nke ma calcium na phosphate ions na-eme ka ọ bụrụ ihe dị mkpa nri maka usoro ndu dị iche iche. Ịghọta ọdịdị ya bụ isi na-enyere aka ịghọta ọrụ ya, site n'iwusi ike ọkpụkpụ na ezé ime ihe dị ka ihe mgbakwunye na nri na mmepụta ihe.

N'ọrụ mmepụta ihe, tricalcium phosphate A na-emepụta ya site na usoro kemịkal dị iche iche, na-agụnye mmeghachi omume nke phosphoric acid na isi iyi calcium dị ka calcium hydroxide ma ọ bụ calcium carbonate. A na-achọta ngwaahịa a na-esi na ya pụta na mpaghara dị iche iche, gụnyere mmepụta nri (dị ka onye na-eme ihe na-eme ihe na-edozi ahụ, ihe oriri mgbakwunye, acidity regulator), ọgwụ (dị ka ihe ndochi na mbadamba), na ọbụna n'ichepụta nke ceramik na fatịlaịza. Ntughari ya sitere na nkwụsi ike kemịkalụ ya na ọrụ ya dị ka isi iyi dị mkpa calcium na phosphate.

Kedu ka Tricalcium Phosphate si akwado ahụike ọkpụkpụ ma gbochie ọkpụkpụ ọkpụkpụ?

Ahụ ike ọkpụkpụ dabere na oke oke oriri calcium, na tricalcium phosphate na-eje ozi dị ka kpọmkwem isi iyi nke a dị mkpa ịnweta. Calcium bụ isi ihe eji arụ ụlọ maka ya nhazi ọkpụkpụ na ịnọgide na-enwe njupụta ọkpụkpụ ná ndụ niile. Ọkpụkpụ anyị na-arụ ọrụ dị ka ebe nchekwa maka calcium, na-ahapụ ya n'ime ọbara mgbe ọ dị mkpa maka ọrụ anụ ahụ ndị ọzọ. Ọ bụrụ calcium nri oriri ezughị oke, ahụ na-ewepụta calcium site n'ọkpụkpụ, nke nwere ike ime ka ike gwụ ya ọkpụkpụ ọkpụkpụ oge n'aga.

Osteoporosis bụ ọnọdụ ji porous, kenkuwa ọkpụkpụ, budata ụba ihe ize ndụ nke ọkpụkpụ ọkpụkpụ. Ọ na-etolitekarị na nzuzo ruo ọtụtụ afọ, na-ejikọkarị ya na ezughi oke calcium na vitamin D oriri, mgbanwe hormonal (dị ka mbelata estrogen mgbe menopause gasịrị), na ịka nká. Mgbakwunye ya na calcium, Ọtụtụ mgbe n'ụdị tricalcium phosphate ma ọ bụ ọzọ ihe mgbakwunye calcium nwere ike nyere aka belata ọkpụkpụ ọkpụkpụ ma belata ihe ize ndụ mgbaji, karịsịa na ndị mmadụ na-enwetaghị ezuru calcium site na nri ha. Na-agba mbọ hụ calcium zuru oke ọkwa bụ isi nkuku nke osteoporosis mgbochi na njikwa.

Nke phosphate akụrụngwa nke tricalcium phosphate na-ekerekwa òkè dị mkpa na nhazi ọkpụkpụ. Ha abụọ calcium na phosphorus bụ ihe jikọrọ ya na kristal hydroxyapatite nke na-enye ọkpụkpụ ike ha na isi ike. Ya mere, tricalcium phosphate na-anapụta ma isi mineral ndị dị mkpa maka ịnọgide na-enwe nhazi skeletal na ọrụ. Na-ewere a ihe mgbakwunye calcium dị ka tricalcium phosphate nwere ike inye aka nke ukwuu n'inweta ihe a tụrụ aro kwa ụbọchị oriri calcium, dị oke mkpa maka igbochi mmetụta na-agwụ ike nke osteoporosis na-akwado n'ozuzu ahụike ọkpụkpụ. Ọmụmụ na-enyocha mgbakwunye na ọkpụkpụ njupụta na-egosikarị mmetụta dị mma nke calcium, karịsịa mgbe ejikọtara ya vitamin D maka nkwalite calcium absorption.

Tricalcium Phosphate vs. Calcium Citrate: Kedu ihe mgbakwunye Calcium dị mma maka gị?

Ịhọrọ nke ziri ezi ihe mgbakwunye calcium nwere ike iyi ihe mgbagwoju anya, yana nhọrọ dịka tricalcium phosphate na calcium citrate ịdị na-enwekarị. Nhọrọ kacha mma na-adaberekarị na mkpa onye ọ bụla, nnabata digestive, na ọnọdụ ahụike dị adị. Tricalcium phosphate na-enye ma calcium na phosphorus, ihe ndị dị mkpa maka ọkpụkpụ na ezé. Ọ na-enwekarị pasentị dị elu nke elementrị calcium site arọ tụnyere calcium citrate, nke pụtara na ị nwere ike ịchọrọ ọgwụ ole na ole ma ọ bụ nta ka ị nweta nke a chọrọ ego nke calcium.

Calcium citrate, N'aka nke ọzọ, a na-atụkarị aro maka ndị nwere afọ acid dị ala (nke a na-emekarị na ndị toro eto ma ọ bụ ndị na-aṅụ acid blockers) n'ihi na ntinye ya anaghị adabere na acid afo. Ebe ọ nwere obere elemental calcium kwa pill karịa calcium carbonate ma ọ bụ nwere ike tricalcium phosphate, nnabata ya nwere ike ịdị na-agbanwe agbanwe maka ụfọdụ ndị. Ha abụọ calcium carbonate na calcium citrate na-ewu ewu ụdị ihe mgbakwunye calcium. Agbanyeghị, calcium citrate a na-ewerekarị na ọ dị obere ka ọ ga-ebute mmetụta dịka afọ ntachi atụlere yana calcium carbonate.

Mgbe atụnyere tricalcium phosphate ka calcium citrate, tụlee isi ihe ndị a:

• Calcium ihe: Tricalcium phosphate na-enyekarị ihe calcium kwa mg.
• Absorption: Calcium citrate A na-etinye ya nke ọma na ma ọ bụ na-enweghị nri ma ọ dịghị achọ nnukwu acid afo. Tricalcium phosphate nnabata na-adịkarị mma mana enwere ike imeziwanye ya mgbe ejiri nri were were ya.
• Nri ndị ọzọ: Tricalcium phosphate na-enye phosphorus, nke dịkwa oke mkpa maka ahụike ọkpụkpụ, ebe calcium citrate naanị na-enye calcium.
• Mmetụta: afọ ntachi nwere ike ime na nke ọ bụla ihe mgbakwunye calcium, ọ bụ ezie na ụfọdụ ụdị nwere ike ka mma karịa ndị ọzọ. Tricalcium phosphate ndidi iche iche.

N'ikpeazụ, iso onye na-ahụ maka ahụike kparịta ụka bụ ụzọ kachasị mma iji chọpụta nke ụdị nke calcium emeju – ma tricalcium phosphate, calcium citrate ma ọ bụ calcium carbonate - kacha mma maka gị kpọmkwem oriri calcium mkpa na profaịlụ ahụike. Ha nwere ike inye aka nyochaa gị calcium nri ọkwa ma kwado ndị kwesịrị ekwesị mgbakwunye na usoro onunu ogwu.

Kedu ihe bụ isi mmalite nri nke Calcium na Phosphate?

Mgbe ihe mgbakwunye dị ka tricalcium phosphate nwere ike inye aka mechie oghere nri, inweta calcium na phosphate isi site na nri dị mma. Magburu onwe isi mmalite nke calcium gụnyere:

• Ngwaahịa mmiri ara ehi: A maara mmiri ara ehi, yogọt, na cheese maka ịdị elu ha calcium ọdịnaya na ezi bioavailability.
• Akwụkwọ nri akwụkwọ ndụ akwụkwọ ndụ: Kale, broccoli, na elu olu na-enye calcium, ọ bụ ezie na nnabata nwere ike ịdị ala karịa site na mmiri ara ehi n'ihi ogige dị ka oxalates.
• Nri agbasiri ike: Ọtụtụ nri, dị ka ihe ọṅụṅụ oroma, ọka, tofu, na mmiri ara ehi ndị sitere n'osisi, ka ejisiri ike calcium.
• Azụ nwere ọkpụkpụ oriri: Sardines mkpọ na salmon dị mma isi mmalite nke calcium.
• Mkpụrụ na mkpụrụ: Almọnd, mkpụrụ chia, na mkpụrụ sesame na-enye aka oriri calcium.

Phosphorus bụ ọbụna ọtụtụ ebe dị na nri karịa calcium. Ọ dị mma nri isi mmalite nke phosphate (na-ejikọta ya na isi mmalite calcium) gụnyere:

• Ihe oriri nwere protein: Anụ, anụ ọkụkọ, azụ̀, àkwá, na mmiri ara ehi ngwaahịa bụ isi mmalite.
• Mkpụrụ na mkpụrụ: Mkpụrụ ugu, mkpụrụ osisi sunflower, na mkpụrụ dị iche iche nwere nnukwu ihe phosphate.
• Mkpụrụ ọka: Agwa na lentil na-enye phosphate.
• Mkpụrụ zuru oke: Oat, quinoa, na ọka wit dum bụ ebe dị mma.
• Nri edoziri: Phosphate ihe mgbakwunye bụ ihe a na-ahụkarị n'ọtụtụ nri ndị edoziri na sodas, na-enye aka nke ukwuu phosphate oriri, mgbe ụfọdụ gabiga ókè.

Iri nri nwere calcium na phosphate-ihe nwere ihe na-eme ka ị nweta mineral ndị a dị mkpa yana nri ndị ọzọ bara uru. Na-adabere naanị na ihe mgbakwunye dị ka tricalcium phosphate pụtara na-efunahụ mmetụta synergistic nke nri dum. Nri kwesịrị ekwesị bụ ntọala maka ezi ihe ahụike ọkpụkpụ na ọdịmma zuru oke, na-ebelata ịdabere na ya mgbakwunye. Na-enyocha gị oriri nke calcium na phosphate site na isi mmalite nri dị mkpa tupu ị gbakwunye a mgbakwunye.

Enwere ike iji Tricalcium Phosphate na mmepụta nri?

Ee, tricalcium phosphate A na-eji ya n'ọtụtụ ebe na ụlọ ọrụ nri, na-ebute ụzọ n'ụzọ anụ ahụ na kemịkal ya karịa naanị uru nri ya dị ka a ihe mgbakwunye calcium. Ọ na-arụ ọrụ dị iche iche, na-eme ka ọ bụrụ ihe mgbakwunye nri nke a na-ahụkarị dị ka nchekwa (GRAS) site na ndị na-ahụ maka nchịkwa dị ka US Food and Drug Administration (FDA).

Ojiji a na-ejikarị gụnyere:

• Ihe na-egbochi ime achịcha: Ikike ya ịmịkọrọ mmiri na-egbochi ngwaahịa powdered dị ka nnu, ngwa nri, shuga ntụ ntụ, na ngwakọta ihe ọṅụṅụ na-agbakọta, na-ahụ na ha na-anọgide na-asọ oyi. Nke a bụ otu n'ime ngwa ya na-emekarị.
• Onye nnọchi anya: Ọ nwere ike inye aka na-edobe udidi nke ụfọdụ nri edoziri.
• Onye na-achịkwa acidity: Tricalcium phosphate nwere ike inye aka ịchịkwa pH itule na nri.
• Ihe mgbakwunye nri: A na-eji ya na-ewusi nri na ihe ọṅụṅụ ike calcium na phosphorus, na-akwalite profaịlụ nri ha. Ị nwere ike ịhụ na a gbakwunyere ya na ọka, ihe e ghere eghe, na ọbụna ụfọdụ mmiri ara ehi ngwaahịa ma ọ bụ ndị ọzọ.
• Emulsifier: Ọ nwere ike inye aka ịgwakọta ihe ndị na-adịghị ejikọta nke ọma, dị ka mmanụ na mmiri.
• Onye nnọchi anya igwe ojii: N'ihe ọṅụṅụ ụfọdụ, ọ na-enye opacity.

Nke tricalcium phosphate eji na nri na-abụkarị nri-ọkwa nri, nke pụtara na ọ na-emezu ụkpụrụ ịdị ọcha siri ike. Ọ bụ ezie na ọ na-enye aka n'ozuzu ya calcium na phosphate ọdịnaya nke nri, ego agbakwunyere maka ebumnuche ọrụ (dị ka mgbochi-caking) na-adịkarị obere ma ọ bụghị isi ihe kpatara ntinye ya. Agbanyeghị, iji ya na nri ndị siri ike na-achọ ozugbo mụbaa oriri calcium. Ndị na-eri nri na-achọ ijikwa nri ịnweta ịnweta ha kwesịrị ịma na ọnụnọ ya na ndepụta ngwa ngwa.

Ego ole Tricalcium Phosphate kwesịrị ị were dị ka mgbakwunye?

Kwesịrị ekwesị onunu ogwu nke tricalcium phosphate dị ka a ihe mgbakwunye calcium na-adabere kpamkpam na ihe onye ọ bụla, gụnyere afọ, mmekọahụ, n'ozuzu ya calcium nri oriri, na kpọmkwem ihe mgbaru ọsọ ahụike dị ka igbochi osteoporosis. Ọ dị mkpa ọ bụghị ka onwe ya dee ihe mgbakwunye calcium mana ịgakwuru onye ọkachamara ahụike. Ha nwere ike nyochaa mkpa gị wee kwado usoro ọgwụgwọ dị mma ma dị irè, a na-atụkarị ya na milligrams (mg) nke elementrị calcium.

Ntuziaka izugbe maka ụbọchị ọ bụla oriri calcium (site na isi mmalite niile, gụnyere nri na ihe mgbakwunye) Ndị otu ahụike na-enye. Maka ndị okenye nọ n'afọ 19-50, Nnyefe Nri Na-atụ aro (RDA) bụ 1,000. mg kwa ụbọchị. Maka ụmụ nwanyị karịrị afọ 50 na ndị nwoke karịrị 70, ndụmọdụ a na-abawanye ruo 1,200 mg kwa ụbọchị iji nyere aka ịlụ ọgụ metụtara afọ ọkpụkpụ ọkpụkpụ ma belata osteoporosis ihe ize ndụ. Cheta, tricalcium phosphate adịghị ọcha calcium; ịkwesịrị ịlele akara maka ego ole elementrị calcium enyere kwa ozi.

Mgbe ị na-atụle mgbakwunye, ọ dị mkpa ịgbakọ nkezi gị calcium nri buru ụzọ were. Ebumnuche bụ iji mgbakwunye iji mebie ọdịiche dị n'etiti ihe oriri gị na ego a tụrụ aro ya, ọ bụghị ịkafe ya nke ukwuu. Na-ewere nnukwu calcium nwere ike ịkpata mmetụta ọjọọ. Dịka ọmụmaatụ, ọ bụrụ na nri gị na-enye 600 mg nke calcium kwa ụbọchị na ebumnuche gị bụ 1,000 mg, ị ga-achọ a mgbakwunye na-enye ihe dịka 400 mg nke elemental calcium. Na-ekewa dose ahụ (dịka ọmụmaatụ, 200 mg ugboro abụọ kwa ụbọchị) nwere ike imeziwanye calcium absorption ma belata mmetụta ndị nwere ike ime dị ka afọ ntachi. Soro ntuziaka ngwaahịa na ndụmọdụ dọkịta gị mgbe niile na-ewere calcium.

Enwere ihe ize ndụ ahụike jikọtara ya na nri Tricalcium Phosphate?

Mgbe tricalcium phosphate na-adịkwa mma mgbe ejiri ya n'ụzọ kwesịrị ekwesị, site na nri ma ọ bụ dịka a mgbakwunye, oke oriri nwere ike ibute ihe ize ndụ ahụike. The isi nchegbu na nnukwu calcium oriri, karịsịa site na ihe mgbakwunye, bụ ike mmepe nke ọnọdụ ọjọọ. Ọ dị mkpa ịnọ n'ime oke akwadoro.

Enwere ike ihe ize ndụ ahụike gụnyere:

• Nkume akụrụ: Oke oke calcium, karịsịa mgbe a na-ewere dị ka ihe mgbakwunye na-enweghị mmiri mmiri zuru oke, nwere ike ịbawanye ihe ize ndụ nke akpụ nkume akụrụ n'ime ndị nwere ike ime. Nke ihe ize ndụ maka akụrụ nkume bụ nchegbu edere nke ọma metụtara ya nnukwu calcium supplementation. Na-ejikọta calcium nwere ma ọ bụ enweghị vitamin D mgbakwunye kwesịrị nlebara anya nke ọma gbasara akụrụ ahụike.
• Hypercalcemia: Ọnọdụ a gụnyere ihe na-adịghị mma nnukwu ọkwa calcium n'ime ọbara (calcium serum). Dị nwayọọ hypercalcemia nwere ike ịkpata mgbaàmà dịka afọ ntachi, ọgbụgbọ, ọnwụ nke agụụ, na ike ọgwụgwụ. siri ike hypercalcemia nwere ike ibute nsogbu ndị ka njọ, gụnyere akụrụ mmebi, mgbu ọkpụkpụ, na mgbagwoju anya.
• Ọrịa obi: Ụfọdụ ọmụmụ atụpụtala njikọ nwere ike ịdị n'etiti nnukwu ihe mgbakwunye calcium oriri na ihe ihe ize ndụ dị ukwuu maka ọrịa obi ihe omume, ọ bụ ezie na ihe akaebe na-agwakọta na esemokwu. Nke ihe ize ndụ nke ọrịa obi njikọ chọrọ nyocha karịa, mana a na-adụ ọdụ ka ị kpachara anya megide oke akwadoro oriri calcium ọkwa, karịsịa site na ihe mgbakwunye. Nke mmetụta nke calcium na ahụike obi dị mgbagwoju anya.
• Ọrịa Prostate: Ụfọdụ nnyocha egosila na ọ ga-ekwe omume ịbawanye ihe ize ndụ na ụmụ nwoke maka ọrịa cancer prostate nwere oke nnukwu calcium oriri, isi site na mmiri ara ehi ngwaahịa ma ọ bụ ihe mgbakwunye, mana njikọ a emebeghị nke ọma.
• Mmekọrịta: Calcium dị elu Ọkwa nwere ike igbochi nnabata nke mineral ndị ọzọ dị ka ígwè, zinc, na magnesium.
• Okwu mgbari nri: Mmetụta ndị nkịtị nke ihe mgbakwunye calcium, gụnyere tricalcium phosphate, nwere ike ịgụnye gas, bloating, na afọ ntachi.

Ọ dị mkpa iji dozie ihe achọrọ calcium zuru oke maka ahụike ọkpụkpụ na igbochi osteoporosis na ikike ihe ize ndụ ahụike nke oke oke mgbakwunye. Na-agbaso n'ụgwọ ụbọchị akwadoro na mkparịta ụka mgbakwunye iji ya na onye na-ahụ maka ahụike bụ ụzọ kacha dịrị nchebe. Onye ọ bụla na-ewere ihe mgbakwunye calcium ọ bụla, gụnyere tricalcium phosphate, kwesịrị ịma ihe ndị a nwere ike ime.

Mara: Ọ bụ ezie na onyonyo a na-egosi Magnesium sulfate, ịnweta mineral dị mma dị ka Magnesium sulfate ma ọ bụ Tricalcium Phosphate gụnyere usoro njikwa mma yiri ya.

Tricalcium Phosphate ọ na-emekọrịta ihe na ọgwụ?

Ee, ihe mgbakwunye calcium, gụnyere tricalcium phosphate, nwere ike iji ọgwụ dị iche iche na-emekọrịta ihe, nwere ike imetụta mmịnye ha ma ọ bụ nrụpụta ha. Ọ bụrụ na ị bụ ịṅụ ọgwụ ụfọdụ, ọ dị mkpa ịkpọtụrụ dọkịta gị ma ọ bụ onye na-ere ọgwụ tupu ịmalite a ihe mgbakwunye calcium. Ha nwere ike ịnye ndụmọdụ gbasara mmekọrịta ndị nwere ike ime ma tụọ oge kwesịrị ekwesị maka ịṅụ ọgwụ gị na mgbakwunye.

Ụfọdụ mmekọrịta ama ama gụnyere:

• Ọgwụ nje: Calcium nwere ike jikọta na ụfọdụ ọgwụ nje, karịsịa tetracyclines (dịka, doxycycline) na fluoroquinolones (dịka, ciprofloxacin), na-ebelata mmịkọ na ịdị irè ha. A na-atụkarị aro ka ị were ihe mgbakwunye calcium opekempe 2 awa tupu ma ọ bụ 4-6 awa mgbe ọgwụ nje ndị a.
• Hormones nke thyroid: Calcium (gụnyere calcium carbonate na enwere ike tricalcium phosphate) nwere ike igbochi nnabata nke levothyroxine, ọgwụ eji agwọ ọrịa hypothyroidism. Na-ewere calcium na levothyroxine ọ dịkarịa ala awa 4 ka a na-adụ ọdụ.
• Bisphosphonates: A na-eji ọgwụ ndị a agwọ ọrịa osteoporosis (dịka ọmụmaatụ, alendronate). Ihe mgbakwunye calcium nwere ike ibelata nnabata ha nke ukwuu. Ekwesịrị iwere ha n'oge dị iche iche nke ụbọchị, na-enwekarị ma ọ dịkarịa ala nkeji 30-60 nkewa, na-agbaso ntuziaka akọwapụtara maka bisphosphonate.
• Antacids dị iche iche: Antacids nwere calcium ma ọ bụ aluminum nwere ike ịbawanye ọkwa calcium ma ọ bụ emetụta phosphate itule mgbe ewere ya na ihe mgbakwunye tricalcium phosphate.
• Thiazide Diuretics: Ọgwụ ọbara mgbali elu ndị a nwere ike ibelata calcium excretion site na akụrụ, nwere ike iduga hypercalcemia ọ bụrụ na ewere ya na nnukwu ego ihe mgbakwunye calcium.
• Ihe mgbakwunye Iron na Zinc: Calcium nwere ike mpi na ígwè na zinc maka absorption na eriri afọ traktị. Na-ewere mineral ndị a ihe mgbakwunye n'oge dị iche iche a na-atụkarị aro.

Ịmara maka mmekọrịta ndị a nwere ike inyere aka hụ na ọgwụ gị na ọgwụ gị ihe mgbakwunye calcium na-arụ ọrụ nke ọma na n'enweghị nsogbu. Gwa onye na-ahụ maka ahụike gị oge niile gbasara ọgwụ na ọgwụ niile ihe mgbakwunye ị na-ewere, gụnyere tricalcium phosphate.

Kedu ọrụ Phosphate na-arụ karịa ahụike ọkpụkpụ?

Ọ bụ ezie na ọ dị mkpa maka nhazi ọkpụkpụ na nhazi n'akụkụ calcium, phosphate (ma ọ bụ phosphorus) na-arụ ọtụtụ ọrụ ndị ọzọ dị mkpa na ahụ. Ọ bụ mineral nke abụọ kachasị n'ime ahụ mgbe e mesịrị calcium, na ọ na-etinye aka na ọtụtụ isi usoro ndu ndu. Na-ewere a mgbakwunye dị ka tricalcium phosphate na-enye ma mineral, ma ịghọta ndị sara mbara ọrụ nke phosphate na-egosi mkpa ọ dị.

Ọrụ ndị dị mkpa nke phosphate gụnyere:

• Mmepụta ike: Phosphate bụ isi akụkụ nke adenosine triphosphate (ATP), ego bụ isi nke anụ ahụ. Usoro metabolic niile na-adabere na ike ewepụtara na ATP.
• Ọdịdị cell: Phospholipids, nke gụnyere phosphate, bụ akụkụ dị mkpa nke akpụkpọ ahụ sel niile, na-achịkwa ihe na-abanye na sel.
• DNA na RNA: Phosphate na-etolite ọkpụkpụ azụ nke DNA na RNA, ihe mkpụrụ ndụ ihe nketa dị mkpa maka uto cell, nrụzi, na mmeputakwa.
• Ntụle Acid-Base: Phosphate Sistemụ nchekwa n'ime ọbara na-enyere aka ịnọgide na-enwe pH kwụsiri ike, nke dị oke mkpa maka ọrụ anụ ahụ.
• Mgbama ekwentị: Phosphate Otu bụ isi n'ịgbalite ma ọ bụ gbanyụọ enzymes na protein site na phosphorylation, usoro bụ isi na akara cell.
• Ụgbọ njem na-edozi ahụ: Phosphate na-etinye aka na mbufe ihe dị iche iche n'ofe cell membranes.

Nyere ya n'ọtụtụ ebe ọrụ, na-ejigide zuru oke phosphorus ọkwa dị mkpa maka ahụike zuru oke. Ọ dabara nke ọma, ụkọ nri dị ụkọ n'ihi ụbara ya n'ọtụtụ nri. Agbanyeghị, ụfọdụ ọnọdụ ahụike ma ọ bụ ọgwụ nwere ike imetụta phosphate itule. Mgbe ihe mgbakwunye tricalcium phosphate inye aka phosphate oriri, isi ihe mere eji ewere ha na-abụkarị maka ha calcium ọdịnaya na-akwado ahụike ọkpụkpụ ma gbochie osteoporosis. Phosphate nwekwara ọtụtụ ọrụ dị egwu karịa ọkpụkpụ.

Cheta na: ogige phosphate metụtara dị ka Disodium phosphate nwekwara dị iche iche ulo oru na nri ngwa.

Kedu ka esi enweta ogo nke Tricalcium Phosphate?

Ịhụ na àgwà na ịdị ọcha nke tricalcium phosphate, karịsịa mgbe ejiri ya dị ka ihe mgbakwunye nri ma ọ bụ nri mgbakwunye, bụ ihe kacha mkpa maka nchekwa na nrụpụta ọrụ. Ndị nrụpụta ama ama na ndị na-ebubata ngwaahịa na-agbaso usoro njikwa mma siri ike yana ụkpụrụ ụlọ ọrụ. Dị ka ndị na-ebubata ihe n'onwe anyị, anyị ghọtara mkpa ndị na-azụ ahịa dị ka Mark Thompson na-etinye na ịdịmma na-agbanwe agbanwe na nkọwapụta.

Akụkụ ndị dị mkpa nke mmesi obi ike gụnyere:

• Isi mmalite ihe akụrụngwa: Iji akụrụngwa dị ọcha dị elu (dị ka phosphoric acid na a pụrụ ịdabere na ya calcium source) bụ nzọụkwụ mbụ. Ntuziaka na adabere na isi mmalite na ndị na-eweta ihe ntụkwasị obi dị oke mkpa.
• Njikwa Usoro nrụpụta: Ịmejuputa njikwa ziri ezi n'oge usoro mmepụta ihe na-eme ka nkwụsi ike na nha nha, njupụta, na ihe mejupụtara kemịkalụ (oke nke calcium ka phosphate). Nke a na-agụnyekarị Ezi Omume nrụpụta (GMP).
• Nlele na nyocha: Nnwale siri ike nke ngwaahịa ikpeazụ na-akwado njirimara, ịdị ọcha, na itinye uche ya. Nke a na-agụnye nlele maka ọla dị arọ (dị ka lead, arsenic, mercury) na mmetọ ndị ọzọ iji hụ na ha nọ n'okpuru oke anabatara nke ndị na-ahụ maka nhazi setịpụrụ (dịka, FDA, EFSA). Anyị eji mma ule ụzọ.
• Asambodo: Ndị nrụpụta na-enwetakarị asambodo dịka ISO 9001 (maka sistemụ njikwa mma) ma ọ bụ FSSC 22000 (maka nchekwa nri). Nkọwapụta ngwaahịa kwesịrị ikwupụta n'ụzọ doro anya nnabata na pharmacopeia dị mkpa (dịka, USP, EP) ma ọ bụ ụkpụrụ codex nri (dịka, FCC). Ndị na-azụ ahịa na-achọkarị nnabata RoHS maka ngwa ụfọdụ, n'agbanyeghị na ọ bụchaghị maka ọkwa nri phosphate onwe ya.
• Akwụkwọ: Inye asambodo nyocha (CoA) na ogbe ọ bụla na-emesi onye ahịa obi ike na ngwaahịa ahụ na-emezu nkọwapụta ekwenyere maka calcium na phosphate ọdịnaya, ịdị ọcha, na njirimara anụ ahụ. Akwụkwọ a na-adabere na ọmụmụ ndị ọgbọ nyochara na ụzọ nnwale akwadoro, a na-emekarị n'ime ụlọ ma ọ bụ site na ụlọ nyocha ndị ọzọ enwetara ikike jikọtara ya ụlọ ọrụ nyocha agụmakwụkwọ.

Maka ndị na-azụ ahịa, ịchọpụta usoro njikwa mma ndị a na-enye ntụkwasị obi na ndị tricalcium phosphate ha na-azụta, ma maka ihe oriri na-ewusi ike, na-emepụta irè ihe mgbakwunye calcium ịlụ ọgụ osteoporosis, ma ọ bụ ojiji ụlọ ọrụ ndị ọzọ. Ndị na-eweta ntụkwasị obi, dị ka Ụdị Chemical, dobe usoro ndị a ụzọ iji wepụta ngwaahịa kemịkalụ na-agbanwe agbanwe, dị elu dị ka tricalcium phosphate na ogige ndị ọzọ metụtara ya dị ka Dicalcium Phosphate ma ọ bụ Monocalcium Phosphate.

Ụzọ isi ihe:

• Tricalcium Phosphate (TCP): Ngwakọta nke calcium na phosphate, dị mkpa maka ọkpụkpụ na ezé, a na-ejikwa dị ka ihe mgbakwunye nri na ihe mgbakwunye calcium.
• Ahụike Ọkpụkpụ: TCP na-enye ihe dị mkpa calcium na phosphorus ịkwado njupụta ọkpụkpụ ma nyere aka gbochie osteoporosis.
• Nhọrọ Mgbakwunye: Atụlere yana calcium citrate, TCP na-enye ndị ọzọ elemental calcium na-enye phosphate, ma calcium citrate ụfọdụ ndị mmadụ nwere ike itinye uche karịa. Kpọtụrụ dọkịta maka ndụmọdụ nkeonwe.
• Isi mmalite nri: Nye ụzọ nri nwere calcium (mmiri ara ehi ngwaahịa, akwụkwọ ndụ akwụkwọ ndụ, nri ndị siri ike) na phosphate isi mmalite (nri protein, ọka dum) n'ịdabere naanị na ihe mgbakwunye.
• Usoro onunu ogwu: Soro akwadoro kwa ụbọchị oriri calcium Ntuziaka (ihe dị ka 1000-1200 mg maka ndị okenye) na iji ihe mgbakwunye naanị iji mechie oghere nri, na-ezere oke oke.
• Ihe ize ndụ nwere ike ime: Mgbakwụnye calcium dị elu oriri nwere ike ịbawanye ihe ize ndụ nke nkume akụrụ, hypercalcemia, na enwere ike ọrịa obi. afọ ntachi bụ mmetụta a na-ahụkarị.
• Mmekọrịta: Ihe mgbakwunye calcium dị ka TCP nwere ike iji ọgwụ nje mee ihe, ọgwụ thyroid, bisphosphonates, na ọgwụ ndị ọzọ / mineral.
• Ọrụ Phosphate: Agafee ọkpụkpụ, phosphate dị oké mkpa maka mmepụta ume, Ọdịdị cell (DNA/RNA, membranes), na akara cell.
• Ogo: Họrọ TCP n'aka ndị na-ebubata ndị na-ahụ maka ịdị mma site na nrụpụta a na-achịkwa, nnwale siri ike maka ịdị ọcha na mmetọ, yana asambodo / akwụkwọ kwesịrị ekwesị.