Dị ka onye nwe ụlọ mmepụta ihe ebe a na China ọkachamara na mmepụta kemịkal, ejirila m ọtụtụ afọ na-emezi njikọ nke ogige inorganic. Aha m bụ Allen, yana na Kands Chemical, anyị ghọtara na maka ndị ọkachamara n'ịzụ ahịa dị ka gị - ikekwe na-achọ inweta ihe ndị a pụrụ ịdabere na ya maka ahịa US - ịdị mma na nkwụsi ike bụ ihe niile. Taa, m chọrọ ikwu banyere kpọmkwem ngwaahịa nke ahụ bụ isi nkuku na ụlọ ọrụ sitere na nri ruo na ọgwụ: dicalcium phosphate dihydrate.
Ị nwere ike mara ya dị ka calcium phosphate diasic, ma ọ bụ hụ naanị koodu CaHPO4 2H2O na mpempe akwụkwọ nkọwa. N'agbanyeghị aha, ndị uru enweghị ike ikwubiga ihe ókè nke ogige a. Anyị tinye ya na ntacha eze, ọka nri ụtụtụ, na ọbụna nri anụmanụ. Ịghọta ihe imeputa na nhazi nke ihe a dị oke mkpa maka ịme mkpebi ịzụrụ ihe ọmụma. Edemede a bara uru ịgụ n'ihi na anyị ga-ewepụ jargon dị mgbagwoju anya wee lelee ngwa bara uru na eziokwu kemịkal nke dị mkpa a phosphate dihydrate. Anyị ga-enyocha ihe mere o ji amasị ya isi iyi nke calcium na phosphorus, ka o si eme na mmiri, na ihe kpatara na ọ dị mkpa na agbụ ọkọnọ gị.
Kedu ihe bụ ngwaahịa kemịkal a na kedu ka esi akọwapụta ya?
Dicalcium phosphate dihydrate bụ kpọmkwem chemical ngwakọta nke nke calcium phosphate ezinụlọ. Dị ka o kwesịrị, a maara ya na chemically dị ka calcium hydrogen phosphate dihydrate. Okwu "dihydrate" na-egosi na ọnụnọ nke abụọ mmiri molekul jikọtara na kristal Ọdịdị, na-anọchi anya ya 2H2O na usoro ya. Ọ bụrụ na ewezuga ụmụ irighiri mmiri ndị a, ọ ga-abụ mmiri na-ekpo ọkụ dicalcium phosphate, nke nwere ubé dị iche iche Njirimara.
Na ụlọ ọrụ, anyị na-ezokarị ya dị ka DCP ma ọ bụ dibasic calcium phosphate dihydrate. Ọ na-apụtakarị dị ka ọcha, enweghị isi, enweghị ụtọ ntụ ntụ ma ọ bụ kristal. Dị ka a emeputa ngwaahịa kemịkal, M hụ na dicalcium phosphate anyị na-arụpụta ụkpụrụ siri ike n'ihi na ọ na-abụkarị eji dị ka nri mgbakwunye ma ọ bụ ihe mgwa ọgwụ. Ọ na-enye nnukwu mineral ọdịnaya, na-eme ka ọ bụrụ ụgbọ ala dị mma maka ịnyefe calcium na phosphorus na ahu.
Akụkụ "dibasic" nke aha ahụ calcium phosphate diasic na-ezo aka n'eziokwu na abụọ nke hydrogen atọm na mbụ phosphoric acid e dochiela ya calcium. Nke a na-eme ka ọ dị ntakịrị acidic karịa Monocalcium Phosphate ma acidic karịa Tricalcium Phosphate. Nke a itule bụ ihe na-enye dicalcium phosphate dihydrate ya pụrụ iche versatility gafee ọtụtụ dị iche iche ngalaba.
Kedu ka anyị ga-esi jikwaa Nkwadebe na nrụpụta nke ogige a?
Nke imeputa nke elu-edu dicalcium phosphate dihydrate bụ kemịkalụ ziri ezi usoro. N'ụlọ ọrụ anyị, ndị nkwadebe na-amalitekarị site na neutralization mmeghachi omume. Anyị na-emeghachi omume phosphoric acid na isi iyi nke calcium. Isi iyi calcium nwere ike ịbụ calcium hydroxide (slaked wayo) ma ọ bụ calcium carbonate.
Nhazi ahụ yiri ihe dị ka nke a:
$$H_3PO_4 + Ca(OH)_2 \ aka nri CaHPO_4 \cdot 2H_2O$$
Njikwa bụ isi. Iji hụ na nhazi nke dihydrate Ụdị karịa ụdị anhydrous, a ga-ahazirịrị nke ọma na ọnọdụ okpomọkụ dị n'okpuru 40°C (104°F). Ọ bụrụ na mmeghachi omume na-akawanye ọkụ, anyị na-atụfu mmiri molekul, na ngwaahịa mgbanwe. Anyị na-enyochakwa ihe pH ọkwa nke ọma. Nke ngwọta kwesịrị ka edobe ya n'ime otu akọwapụtara isi ma ọ bụ ntakịrị acidic oke iji kwalite uto kristal ziri ezi.
Ozugbo kristal na-etolite, a na-ekewapụ ha na mmiri mmiri, na-asachapụ iji wepụ adịghị ọcha (dị ka ngafe acid ma ọ bụ sodium nnu ma ọ bụrụ na ejiri ya mee ihe), na akpọnwụwo. Usoro ihicha ahụ dị nro; oke okpomọkụ ga-ewepụ ya 2H2O, na-emebi ihe dicalcium phosphate dihydrate. Dị ka onye na-ebubata ahịa dị ka USA na Australia, anyị maara na nha ọka na-adịghị agbanwe agbanwe ma ọ bụ ịdị ọcha bụ ihe mgbu maka ndị na-azụ ahịa dị ka Mark. N'ihi ya, anyị ulo oru usoro na-emesi ike anọgidesi na ọ bụla ogbe nke dicalcium phosphate.
Kedu ihe kpatara Calcium Phosphate ji dị mkpa maka ụlọ ọrụ ọgwụ?
N'ime ọgwụ ụwa, dicalcium phosphate dihydrate bụ superstar excipient. A excipient bụ ihe emepụtara n'akụkụ ihe na-arụ ọrụ nke ọgwụ. A na-ejikarị ya eme ihe dị ka a mbadamba mbadamba na ụfọdụ ọgwụ nkwadebe. Gịnị kpatara? N'ihi na dicalcium phosphate nwere mma eruba Njirimara na compressibility.
Mgbe onye nrụpụta kwesịrị ịmepụta a mbadamba nkume, ha chọrọ nnukwu ihe nke ahụ ga-ejide ọdịdị ya mgbe a na-agbanye ya ma na-agbajikwa nke ọma na afọ. Ọkpụkpụ calcium phosphate dihydrate dabara ụgwọ a nke ọma. Ọ bụ insolution na mmiri mana agbaze ngwa ngwa na gburugburu acidic nke afọ. Nke a na-eme ka a hụ na ewepụtara ọgwụ ahụ kpọmkwem ebe ọ dị mkpa.
Ọzọkwa, ọ bụghị hygroscopic, nke pụtara na ọ naghị amịkọrọ mmiri sitere na ikuku. Nke a dị mkpa maka nkwụsi ike nke ọgwụ ndị nwere mmetụta. Ọ bụrụ na ị na-eji ihe ndochi na-amịkọrọ mmiri, ọgwụ na-arụ ọrụ nwere ike ịda mbà tupu onye ọrịa ahụ emepee karama ahụ. Site n'iji dicalcium phosphate dihydrate, ọgwụ ụlọ ọrụ na-ahụ maka ngwaahịa ha ogologo ndụ. Ọ na-eme dị ka a pụrụ ịdabere na diluent, na-enye ndị mbadamba nkume nha na ọdịdị dị mkpa maka ndị ọrịa na-edozi ngwa ngwa.
Kedu otu esi eji ngwakọta a dị ka ihe mgbakwunye nri?
Ọ bụrụ na ịlele akara ndị dị n'ụlọ nri gị, ị ga-ahụ ya dicalcium phosphate. Ọ bụ ebe niile eji dị ka nri mgbakwunye n'ihi ọtụtụ ihe. N'ụzọ bụ isi, ọ na-eje ozi dị ka ihe na-eko achịcha. Mgbe ejikọtara ya na alkali. dicalcium phosphate dihydrate na-emeghachi omume iji mepụta carbon dioxide gas. A na-ejide gas a na mgwakota agwa, na-eme ka ọ bilie. Mgbe Sodium acid pyrophosphate dị ngwa ngwa, DCPD na-enye mmeghachi omume nwayọ, na-agbanwe agbanwe, nke zuru oke maka ụfọdụ anụ ezi.
E wezụga ihe iko achịcha, ọ bụ texturizer na stabilizer. N'ime nri ụtụtụ ọka, a na-agbakwunyekarị ya iji wusie ike nri ya na calcium. Ebe ọ bụ na ọtụtụ ndị anaghị enweta nke ọma calcium site na mmiri ara ehi naanị, na-agbakwụnye dicalcium phosphate ngwaahịa ndị sitere na ọka na-enyere aka imechi oghere nri ahụ. A na-ahụkwa ya na ntụ ọka na ngwaahịa noodle bara ụba.
Maka nri ụlọ ọrụ, na uru dị na nnọpụiche ya. Dicalcium phosphate dihydrate enweghị ụtọ na enweghị isi, yabụ na ọ naghị agbanwe profaịlụ ụtọ nke ahụ ngwaahịa. Ọ na-enye naanị uru na-arụ ọrụ-ma nke ahụ bụ ebuli, nhazi, ma ọ bụ ihe oriri na-edozi ahụ-na-enwetaghị ụzọ nke ụtọ.
Kedu ọrụ ọ na-arụ na nri na nri anụmanụ?
Anyị enweghị ike ikwu maka ya dicalcium phosphate n'ekwughị oke ọrụ ọ na-arụ n'ọrụ ugbo. Ọ bụ isi ihe na anụmanụ nri. Anụ ụlọ, anụ ọkụkọ, na anụ ụlọ niile chọrọ nnukwu ego calcium na phosphorus maka mmepe nke skeletal na ọrụ metabolic. Dicalcium phosphate dihydrate dị nke ukwuu n'usoro ihe ọmụmụ, nke pụtara na ụmụ anụmanụ nwere ike ịgbari ngwa ngwa ma nweta nri na-edozi ahụ na ya.
N'ime nkịta na-emeso na nri anụ ụlọ azụmahịa, dicalcium phosphate na-eme ka ndị enyi anyị na-ewe iwe jisie ike ọkpụkpụ njupụta na ahụike ezé. Maka anụ ụlọ, ọ kadị mkpa karịa. Enweghị ụkọ na phosphorus nwere ike ibute mbelata uto uto na ahụike adịghị mma. Site na itinye calcium phosphate diasic N'ime nri ha, ndị ọrụ ugbo na-ahụ maka nrụpụta dị elu na ọdịmma anụmanụ.
Anyị na-enyekarị nke a na granular ụdị maka nri ngwa iji belata uzuzu ma melite ngwakọta na ihe ndị ọzọ. Ọ bụ nchekwa, rụọ ọrụ nke ọma isi iyi nke calcium na phosphorus nke na-akwado usoro inye nri zuru ụwa ọnụ na-amalite na ọkwa ugbo.
Kedu ka Solubility na mmiri si emetụta ngwa ya?
Otu n'ime nkọwa njirimara nke dicalcium phosphate dihydrate bụ profaịlụ solubility ya. Ọ fọrọ nke nta ka ọ ghara ịsacha ya mmiri. Ọ bụ ezie na nke a nwere ike ịdị ka ihe ọghọm, n'ọtụtụ ngwa, ọ bụ uru. N'ihi na ọ naghị agbaze ozugbo n'ime mmiri, ọ na-enye ntọhapụ nke nri na-adịgide adịgide.
Agbanyeghị, solubility ya na-agbanwe nke ukwuu pH. Ọ na-agbaze ngwa ngwa na acids dilute, dị ka itughari hydrochloric acid ma ọ bụ citric acid. A na-eji ihe a eme ihe n'ụlọ ọrụ dị iche iche. Dịka ọmụmaatụ, n'ime ala ubi nke nwere acidic. dicalcium phosphate na-agbaji ka oge na-aga, na-enye ihe na-adịgide adịgide phosphorus ịkụ mgbọrọgwụ.
Na ụlọ nyocha ma ọ bụ nhazi mmepụta ihe, ọ bụrụ na anyị kwesịrị igbari ya, anyị ga-agbadata pH nke ngwọta. Ịghọta mmekọrịta a na mmiri na acid dị oké mkpa maka ndị na-emepụta ihe. Ọ bụrụ na ị na-agbalị ịmepụta ngwaahịa mmiri mmiri doro anya, phosphate dihydrate nwere ike ịmalite ma ọ bụrụ na ejighị acidity nke ọma. Mmiri mmiri dị ala a na-emekwa ka ọ kwụsie ike na gburugburu iru mmiri, nke dị mma maka nchekwa na njem.
A na-eji ya na mmepụta na nhazi ihe ọṅụṅụ?
Ọ bụ ezie na ọ dị obere karịa na nri siri ike, dicalcium phosphate na-achọta otu ngwa n'ime ihe ọṅụṅụ ụlọ ọrụ, karịsịa n'ime ihe ọṅụṅụ siri ike. Otú ọ dị, n'ihi na ya ala solubility na larịị mmiri, a na-ejikarị ya eme ihe na nkwusioru ma ọ bụ na ihe ọṅụṅụ acidic ebe ọ nwere ike igbari.
N'ihe ọṅụṅụ nke mmiri ara ehi ma ọ bụ mmiri ara ehi ndị ọzọ sitere na osisi (dịka mmiri ara ehi soy ma ọ bụ almond), dicalcium phosphate dihydrate na-eme dị ka a calcium isi iyi. N'ebe a, a ga-akụrịrị ya ka ọ bụrụ ezigbo mma ntụ ntụ iji gbochie mmetụ ọnụ na iji hụ na ọ na-akwụsịtụ n'ime mmiri mmiri.
Ọ na-enyere aka ịchekwa ihe ihe ọṅụṅụ, na-edobe nkwụsi ike nke ndị na-edozi ahụ na igbochi curdling. Agbanyeghị, ndị na-emepụta ihe ga-akpachara anya. Ọ bụrụ na ihe ọṅụṅụ na-anọpụ iche ma doo anya, calcium phosphate anaghị abụkarị nhọrọ mbụ; nnu soluble dị ka Calcium lactate (nke a na-ejikarị maka nchekwa mana yana ọdịnaya calcium) nwere ike ịka mma. Ma maka urukpuru, ihe ọṅụṅụ na-edozi ahụ, DCP bụ nhọrọ na-eri ọnụ na nke na-edozi ahụ.
Kedu ụdị ngwa eze na-adabere na ntụ ntụ a?
Mepee tube nke ihe ntacha eze, na enwere ohere dị mma ị na-ele anya dicalcium phosphate dihydrate. Na ụlọ ọrụ nlekọta eze, a na-ejikarị ya eme ihe dị ka a onye na-egbuke egbuke. Nke kristal Ọdịdị nke dihydrate na-esi ike iji wepụ ihe ncheta na ntụpọ na ezé mana ọ dị nro nke na ọ dịghị emebi enamel.
Nke a ụdị A na-ahọrọ nke abrasive karịa ihe ndị ọzọ siri ike dị ka silica n'ụdị ụfọdụ. Ọ na-ehicha ezé nke ọma, na-enyere aka igbochi mmepe nke tartar na idokwa chịngọm ahụ ike. Ọzọkwa, n'ihi na ọ nwere calcium na phosphate, ọ nwere ike na-enyere aka na remineralization nke eze n'elu, ọ bụ ezie na isi ọrụ ya bụ ihicha anụ ahụ.
A na-ejikwa ya na ciment eze na ihe ndozi. Ihe kemịkalụ mmeghachi omume n'etiti calcium ion na phosphate ions bụ ihe ndabere maka nhazi nke ezé mmadụ (nke bụ hydroxyapatite n'ụzọ dị ukwuu), na-eme dicalcium phosphate ihe biomimetic—nke na-eṅomi bayoloji.
Kedu ihe kpatara tinye Dicalcium Phosphate na mgbakwunye nri?
Nke nri mgbakwunye ahịa na-aga n'ihu, na dicalcium phosphate bụ isi ihe. Mgbe ị na-ewere multivitamin ma ọ bụ nke kwụ ọtọ calcium mgbakwunye, lelee akara. Ị ga-ahụkarị calcium phosphate diasic edepụtara.
Anyị tinye ya n'ihi na ọ na-emepụta obere mbadamba nkume nke nwere pasent dị elu nke elemental calcium. Nke a na-enye ohere ka ndị na-emepụta ihe dabara n'ụdị dị mkpa kwa ụbọchị n'ime pill nke dị mfe ilo. N'adịghị ka nnukwu carbonate salts, phosphate dihydrate na-achịkọta ntụmadị nri n'ụdị kọmpat.
Ọzọkwa, ọ na-enye phosphorus, nke dị mkpa n'ihi na ahu nagide ihe calcium nke ọma maka ọkpụkpụ rụkwaa na anụ ahụ mmezi. Ọ bụ ngwugwu nri abụọ. Maka ndị na-azụ ahịa bụ ndị anaghị anabata lactose ma ọ bụ vegan, ihe mgbakwunye nwere kemịkalụ dicalcium phosphate emepụtara site na isi mmalite ịnweta na-enye nhọrọ dị oke egwu maka nri sitere na mmiri ara ehi.
Kedu ihe na-eme n'oge mbelata okpomọkụ na pyrophosphate?
Dị ka a kemist, m na-ahụ thermal Njirimara nke dicalcium phosphate dihydrate na-adọrọ mmasị. Ọ bụrụ na ị kpoo nke a ngwaahịa, ọ na-enwe mgbanwe. N'ihe dị ka 60-70 Celsius C, ọ na-efunahụ ụmụ irighiri mmiri ya ka ọ ghọọ mmiri na-ekpo ọkụ dicalcium phosphate. Ọ bụrụ na ị na-aga n'ihu na-ekpo ọkụ na okpomọkụ dị elu (ihe dị ka 400 ° C - 500 Celsius C), condensation. mmeghachi omume emee.
Abụọ molekul nke dicalcium phosphate jikọta, na-ahapụ mmiri, na imepụta Calcium pyrophosphate (Ca2P2O7). Usoro ahụ pyrophosphate n'ụzọ nkịtị pụtara "ọkụ phosphate," na-egosi na ọ na-amụ site okpomọkụ.
$$2CaHPO_4 \akụ aka nri Ca_2P_2O_7 + H_2O$$
Nke a calcium pyrophosphate dị iche kemịkalụ anụmanụ. Ọ bụ ọbụna ihe na-esighi ike ma na-eji ya dị ka abrasive dị nro na fluoride ihe ntacha eze n'ihi na ọ naghị emeghachi omume na fluoride (n'adịghị ka dicalcium phosphate dihydrate, nke nwere ike igbochi nkwụsi ike nke fluoride mgbe ụfọdụ). Ịghọta omume okpomọkụ a dị mkpa maka ndị imeputa nke pụrụ iche eze ihe na ihe seramiiki.
Isi ihe eji eme ihe
- Dicalcium phosphate dihydrate (CaHPO4 2H2O) bụ ihe dị iche iche calcium phosphate Ngwakọta eji n'ofe nri, ọgwụ na ọrụ ugbo.
- Ọ na-eje ozi dị ka ihe dị mkpa isi iyi nke calcium na phosphorus maka ma mmadụ ma anụmanụ, na-akwado ọkpụkpụ na anụ ahụ ahụike.
- N'ime ọgwụ ụlọ ọrụ, ọ bụ a họọrọ mbadamba mbadamba na ụfọdụ ọgwụ preparations n'ihi njupụta ya na njupụta ya.
- Ọ na-arụ ọrụ dị ka ihe na-eko achịcha na ihe mgbakwasị ụkwụ mgbe eji dị ka nri mgbakwunye n'ime anụ ezi na nri ụtụtụ ọka.
- Nke nkwadebe gụnyere imeghachi omume phosphoric acid na isi iyi calcium dị ka hydroxide n'okpuru nchịkwa pH na okpomọkụ.
- Ọ bụ insolution na mmiri mana agbaze n'ime acid, nke na-enyere aka mgbari ya na afọ.
- Ọ na-eme dị ka nwayọọ onye na-egbuke egbuke n'ime ihe ntacha eze iwepu tartar na-enweghị mmebi enamel.
- Ịkụnye ngwakọta ahụ nwere ike ịtụgharị ya n'ime calcium pyrophosphate, nke nwere ngwa ụlọ ọrụ pụrụ iche nke ya.
Oge nzipu: Dec-10-2025
