Taw qhia:
DiChole Phosphate (DCP), tseem hu ua calphate hydrogen phosphate, yog qhov sib txuas ntawm cov ntxhia uas pom tias muaj kev lag luam thoob plaws hauv ntau yam kev lag luam. Ib qho ntawm nws cov ntawv thov tseem ceeb yog nyob rau hauv lub luag hauj lwm kws tshuaj, uas nws ua lub luag haujlwm tseem ceeb li kev tos txais hauv cov ntsiav tshuaj tsim. Hauv tsab xov xwm no, peb yuav delve mus rau hauv cov ntsiav tshuaj ntawm cov ntsiav tshuaj tsim, tshawb nws cov khoom, thiab nkag siab yog vim li cas nws yog qhov kev xaiv nrov ntawm cov chaw muag tshuaj.
Cov khoom ntawm dicalcium phosphate:
Dcp yog cov hmoov dawb, tsis muaj ntxhiab uas yog insoluble hauv dej tab sis tau yooj yim yaj nyob rau hauv dilute hydrod acid. Nws cov mis mis yog cahpo4, qhia nws cov lej ntawm calcium cations (CA2 +) thiab phoosphate Anions (HPO4 2-). Qhov no sib xyaw no yog muab tau los ntawm calcium hydrogen phosphate cov khoom siv ua kom zoo nkauj thiab undergoes lub tshuab ua kom zoo nkauj phoscium phim rau kev siv tshuaj.
Cov txiaj ntsig ntawm dicalcium phosphate hauv cov ntsiav tshuaj tsim:
Diluent thiab Binder: Nyob rau hauv ntsiav tshuaj tsim, DCP ua raws li depuent, uas pab kom nce cov ntsiav tshuaj me thiab loj. Nws muab cov ntsiav tshuaj kom zoo nkauj, tso cai rau cov ntsiav tshuaj kom muaj kev tswj hwm lawv cov qauv thiab kev ntseeg siab thaum lub sijhawm tsim khoom. DCP kuj ua raws li phau ntawv qhia, ua kom cov khoom xyaw ua ke sib txuas ua ke.
Daim Qauv Tso Tawm: DCP muaj cov khoom uas ua rau nws xaiv qhov zoo tshaj plaws rau kev tswj hwm kev tawm tswv yim. Los ntawm kev kho cov particle loj thiab cov khoom sib txawv ntawm dicalcium phosphate, Tshuaj Ntsuam Xyuas Tshuaj Muaj peev xwm ua tiav cov kev ua tau zoo ntawm kev ua tau zoo thiab ua kom ua raws.
Bioavailability ua kom tiav: Txhim kho cov xyoob ntoo muaj zog ntawm cov khoom xyaw tshuaj muaj zog (APIs) yog qhov tseem ceeb rau cov tshuaj zoo. DiChole Phosphate tuaj yeem txhim kho kev sib nrauj thiab solubility ntawm apis hauv cov ntsiav tshuaj, yog li txhim kho lawv cov bioavailability. Qhov no muaj txiaj ntsig tshwj xeeb yog rau cov tshuaj tsis zoo uas yuav tsum tau txhim kho cov nqi nqus.
Kev sib raug zoo: DCP cov khoom pov thawj zoo tau sib raug zoo nrog ntau yam ntawm cov khoom xyaw tshuaj. Nws tuaj yeem cuam tshuam nrog lwm lub ntsiav tshuaj expients thiab apis yam tsis muaj kev ua rau tshuaj lom neeg lossis kev sib cais ntawm cov ntsiav tshuaj. Qhov no ua rau nws muaj ntau yam kev zam kom haum rau ntau yam tshuaj.
Kev Nyab Xeeb thiab Kev Cai Tswj Pom Zoo: Doccium Phosphate siv nyob rau hauv cov ntsiav tshuaj undergoes nyuaj tswj kev ntsuas kom ntseeg tau tias nws ua tau raws li cov qauv kev nyab xeeb. Lub npe nrov ntawm cov chaw tsim khoom los ntawm cov neeg muag khoom los ntawm cov kev tswj hwm txhim khu kev qha, xws li cov kev ua lag luam zoo (GMP) thiab tshuaj noj khoom haus.
Xaus:
Kev siv ntawm dicalcium phosphate hauv cov ntsiav tshuaj tsim muaj ntau qhov zoo rau kev lag luam kws tshuaj. Nws cov yam ntxwv raws li ib tug neeg rau txim, thiab tswj hwm-tso tawm kev vam meej, thiab kev tawm yeeb tshuaj profiles, thiab bioavailability ntawm APIs. Ntxiv mus, nws compatibility nrog lwm cov khoom xyaw thiab nws cov ntaub ntawv muaj kev nyab xeeb ntxiv pab nws cov koob meej ntawm cov tshuaj lag luam.
Thaum xaiv dicalcium phosphate rau cov ntsiav tshuaj raug, nws yog qhov tseem ceeb uas yuav xav txog kev tswj hwm zoo li kev tswj hwm zoo li kev tswj hwm, tswj lub npe nrov. Kev xaiv rau cov neeg muag khoom ntseeg uas tswj hwm cov qauv nruj ua kom ntseeg tau tias muaj kev sib xws thiab muaj txiaj ntsig zoo DCP.
Raws li cov chaw tsim khoom lag luam txuas ntxiv mus rau hauv cov tshuaj ua haujlwm, dicalcium phosposation hauv ntsiav tshuaj yuav nyob rau hauv cov txiaj ntsig thiab kev vam meej ntawm ntau yam tshuaj hauv kev ua lag luam.
Lub Sijhawm Post: Sep-12-2023
